Biochemical Studies on Guanidine-Bodies. VI

Studies on Digitalis VI

T IS undisputed that the administration of digitalis to patients with many forms of congestive heart failure results in an improvement in both the clinical state and in the abnormal circulatory dynamics that are characteristic of heart failure.'-6 The effects of digitalis in subjects without heart failure are less well defined. Although some glycosides augment the contractile force of nonfailin...

Biochemical studies on inositol. VI. Mechanism of cleavage of inositol to D-glucuronic acid.

In a previous publication (1, Paper V of this series) the purification and properties of the inositol-cleaving enzyme were described. It was shown that a highly purified enzyme was obtained from rat kidneys which cleaved inositol to D-ghCUI’OniC acid. The purified enzyme was shown to possess SH groups and 1 gram atom of iron per mole of enzyme. Both the SH groups and the iron are necessary for ...

Clinical and Biochemical Studies on the Basis of Ketone Bodies in Cattle : I. Blood Ketone Bodies in Normal Dairy Cattle

Biochemical Studies on Shock

During and following the production of shock by hemorrhage in the normal, suprareno-demedullated, and suprarenalectomized rat, the following significant changes in amino acid and carbohydrate metabolism have been observed. 1. In the intact, suprareno-demedullated, and suprarenalectomized rat there is a progressive rise in the whole blood and plasma amino acid nitrogen levels during and after a ...

Biochemical Studies on Inositol

In a previous publication (1, Paper V of this series) the purification and properties of the inositol-cleaving enzyme were described. It was shown that a highly purified enzyme was obtained from rat kidneys which cleaved inositol to D-ghCUI’OniC acid. The purified enzyme was shown to possess SH groups and 1 gram atom of iron per mole of enzyme. Both the SH groups and the iron are necessary for ...